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In human genetics, Haplogroup C (M130) is a Y-chromosome haplogroup.

Haplogroup C contains the M168 change, which is present in all Y-chromosome haplogroups except A and B. Haplogroup C seems to have come into existence shortly after M168 was introduced.

It represents a great coastal migration along Southern Asia, into Southeast Asia and Australia, and up the Asian coast. It is believed to have migrated to the Americas some 6,000-8,000 years before present, and was carried by Na-Dené speaking peoples into the North West Pacific coast of America.

Haplogroup C contains the polymorphism, very common in Central Asia, which is believed to be that of Genghis Khan, spread wide during the Mongol conquest of Asia.

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