INFLUENCE OF CHARACTER OF ANTIBODY UPON VELOCITY OF FLOCCULATION
William C. Boyd Ph.D.
The Journal of Experimental Medicine, Vol 74, 369-386, Copyright, 1941, by The Rockefeller Institute for Medical Research New York
From Evans Memorial, Massachusetts Memorial Hospitals, and Boston University School of Medicine, Boston
Results of a thorough study of the rates of flocculation of 20 antisera when mixed with their antigens in all proportions are presented. The relation between the alpha (constant antibody) and � (constant antigen) optima is discussed. It is suggested that most of the antisera examined can be classified into two main types, one of which, the H type, gives an optimum by both the alpha and � procedures, whereas the R type gives an optimum only by the former technique. It appears that these differences can only be accounted for by the influence of differences in the physical and chemical properties of the various antibodies. Submitted on June 18, 1941