The INDIVIDUALIST

A Wiki about biochemical individuality

Glycomics

See Also

Description

A group of enzymes with the general formula cmp-n-acetylneuraminate:acceptor n-acetylneuraminyl transferase. They catalyze the transfer of n-acetylneuraminic acid from cmp-n-acetylneuraminic acid to an acceptor, which is usually the terminal sugar residue of an oligosaccharide, a glycoprotein, or a glycolipid.

Defects in sialyltransferase activity are an important component of what are termed 'aberrant forms of glycosylation' that are often seen in malignant tissue.

Certain saponins found in plants and legumes, called soyasaponins are potent inhibitors of sialyltransferase activity.

Nomenclature

Approved SymbolAliasesApproved Name
SIAT1CD75,ST6Gal Isialyltransferase 1 (beta-galactoside alpha-2,6-sialyltransferase)
SIAT2may be same as SIAT4sialyltransferase 2 (monosialoganglioside sialyltransferase)
SIAT3ST6GalNAc I(no human sequence as yet)
SIAT4AST3O, SIATFL, ST3GalA.1, ST3Gal Isialyltransferase 4A (beta-galactoside alpha-2,3-sialyltransferase)
SIAT4BST3Gal IIST3GalA.2sialyltransferase 4B (beta-galactoside alpha-2,3-sialyltransferase)
SIAT4CCGS23, SIAT4, NANTA3, ST3Gal IV, STZ, SAT3sialyltransferase 4C (beta-galactoside alpha-2,3-sialyltransferase)
SIAT5*sialyltransferase 5 (galactosyldiacylglycerol alpha 2,3-sialyltransferase)
SIAT6ST3Gal IIIsialyltransferase 6 (N-acetyllactosaminide alpha 2,3-sialyltransferase)
SIAT7ST6GalNAc II, III, IV?SThMsialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6- sialyltransferase)
SIAT7ST6GALNAC IIIsialyltransferase 7C
SIAT7DST6GALNACIV,ST6GALNAC4, SIAT3Csialyltransferase 7D ((alpha-N-acetylneuraminyl-2,3- beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase)
SIAT7E>MGC3184, ST6GalNAcVsialyltransferase 7E
SIAT8AST8Sia Isialyltransferase 8 (alpha-N-acetylneuraminate: alpha-2,8-sialyltransferase,GD3 synthase)
SIAT8BST8Sia II, STXsialyltransferase 8B (alpha-2, 8-sialytransferase)
SIAT8CST8Sia IIIsialyltransferase 8C (alpha2,3Galbeta1,4GlcNAcalpha 2,8-sialyltransferase)
SIAT8DST8Sia IV, PSTsialyltransferase 8D (alpha-2, 8-polysialytransferase)
SIAT8EST8Sia Vsialyltransferase 8E (alpha-2, 8-polysialytransferase)
SIAT9ST3GalVsialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase;GM3 synthase)
SIATL-sialyltransferase-like

Genebase and protein links

Approved NameChromosome LocationEC numberSequence Acc.SWISS-PROTOMIM Number
sialyltransferase 1 (beta-galactoside alpha-2,6-sialyltransferase)3q27-q282.4.99.1X62822, X17247, X54363P15907109675
sialyltransferase 2 (monosialoganglioside sialyltransferase)*2.4.99.2***
(no human sequence as yet)*2.4.99.3***
sialyltransferase 4A (beta-galactoside alpha- 2,3-sialyltransferase)82.4.99.4L29555, L13972, AF059321Q11201*
sialyltransferase 4B (beta-galactoside alpha- 2,3-sialyltransferase)1p34-p212.4.99.4U63090, X96667**
sialyltransferase 4C (beta-galactoside alpha-2,3-sialyltransferase)11q23-q242.4.99.4X74570, L23767Q11206104240
sialyltransferase 5 (galactosyldiacylglycerol alpha 2,3-sialyltransferase)*2.4.99.5***
sialyltransferase 6 (N-acetyllactosaminide alpha 2,3-sialyltransferase)*2.4.99.6L23768Q11203*
sialyltransferase 7 ((alpha-N-acetylneuraminyl- 2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6- sialyltransferase)172.4.99.7??U14550**
sialyltransferase 7C1*AK091215**
sialyltransferase 7D ((alpha-N-acetylneuraminyl- 2,3- beta-galactosyl-1,3) -N-acetyl galactosaminide alpha-2,6-sialyltransferase)9q34*L32867**
sialyltransferase 7E1p31.1*AK095758**
sialyltransferase 8 (alpha-N-acetylneuraminate: alpha-2,8-sialyltransferase, GD3 synthase)122.4.99.8L32867, D26360, L43494, X77922Q92185601123
sialyltransferase 8B (alpha-2, 8-sialytransferase)15q262.4.99.-U82762,U33551Q92186602546
sialyltransferase 8C (alpha2,3Galbeta1,4GlcNAcalpha 2,8-sialyltransferase)18*AF004668**
sialyltransferase 8D (alpha-2, 8-polysialytransferase)5q212.4.99.-L41680Q92187602547
sialyltransferase 8E (alpha-2, 8-polysialytransferase)18*U91641**
sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; GM3 synthase)*2.4.99.9AF105026**
Gal beta 1,4GlcNAc alpha-2,3-sialyltransferase**AB022918**
sialyltransferase-like 1-****

Attribution

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