The INDIVIDUALIST

A Wiki about biochemical individuality

Genomics

See Also

Description

  • Official Symbol: TEP1 and Name: telomerase-associated protein 1
  • Gene type: protein coding
  • Gene name: TEP1
  • Gene description: telomerase-associated protein 1
  • Gene aliases: TP1; TLP1; p240; TROVE1; VAULT2
  • Chromosome: 14; Location: 14q11.2

Summary

This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans.

Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle (By similarity)

Abstracts

TP1 expression did not change after cisplatin exposure for 72 hours. PubMed

Telomerase activity and hTERT, TP-1 mRNA expression are up-regulated in esophageal squamous cell carcinoma PubMed

Expression of telomerase activity and its subunit level in pancreatic carcinoma significantly correlate with the clinical stage of pancreatic carcinoma. PubMed

TEP1, hTR, hsp90, p23, and dyskerin remained at high and unchanged levels throughout up- or down regulation of telomerase activity. PubMed

Links

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